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Bibliography of Publications and Abstracts

Catalyst for a Cure Principal Investigators at the GRF Annual Benefit
Catalyst for a Cure Principal Investigators at the GRF Annual Benefit

The Catalyst for a Cure research scientists have achieved important peer acknowledgment in key science publications.

The following list of Catalyst For a Cure (CFC) Publications and Abstracts represents research results published since 2005.

Papers and manuscripts

Brimonidine prevents axonal and somatic degeneration of retinal ganglion cell neurons.
Lambert WS, Ruiz L, Crish SD, Wheeler LA, Calkins DJ.
Mol Neurodegener. 2011 Jan 13;6(1):4.

Neurodegeneration in glaucoma: progression and calcium-dependent intracellular mechanisms.
Crish SD, Calkins DJ.
Neuroscience. 2011 Mar 10;176:1-11. Epub 2010 Dec 25. Review.

Optic neuropathy due to microbead-induced elevated intraocular pressure in the mouse.
Chen H, Wei X, Cho KS, Chen G, Sappington R, Calkins DJ, Chen DF.
Invest Ophthalmol Vis Sci. 2011 Jan 5;52(1):36-44.

Early microglia activation in a mouse model of chronic glaucoma.
Bosco A, Steele MR, Vetter ML.
J Comp Neurol. 2011 Mar 1;519(4):599-620.

Myelination transition zone astrocytes are constitutively phagocytic and have synuclein dependent reactivity in glaucoma.
Nguyen JV, Soto I, Kim KY, Bushong EA, Oglesby E, Valiente-Soriano FJ, Yang Z, Davis CH, Bedont JL, Son JL, Wei JO, Buchman VL, Zack DJ, Vidal-Sanz M, Ellisman MH, Marsh-Armstrong N.
Proc Natl Acad Sci U S A. 2011 Jan 18;108(3):1176-81.

Retinal ganglion cell loss in a rat ocular hypertension model is sectorial and involves early optic nerve axon loss.
Soto I, Pease ME, Son JL, Shi X, Quigley HA, Marsh-Armstrong N.
Invest Ophthalmol Vis Sci. 2011 Jan 21;52(1):434-41.

Glaucomatous optic nerve injury involves early astrocyte reactivity and late oligodendrocyte loss.
Son JL, Soto I, Oglesby E, Lopez-Roca T, Pease ME, Quigley HA, Marsh-Armstrong N.
Glia. 2010 May;58(7):780-9.

The microbead occlusion model: a paradigm for induced ocular hypertension in rats and mice
Sappington, RM., Carlson, BJ., Crish, SD. & Calkins, D.J. (2010)
Investigative Ophthalmology & Visual Science, 51:207-16.

Metabolic Vulnerability Disposes Retinal Ganglion Cell Axons to Dysfunction in a Model of Glaucomatous Degeneration
Baltan, S., Inman DM., Danilov, CA., Morrison, RS., Horner, PJ. & Calkins, D.J. (2010) Journal of Neuroscience, 30:5644-5652.

Distal axonopathy with structural persistence in glaucomatous neurodegeneration
Crish, SD., Sappington, R.M., Inman DM., Horner, PJ. & Calkins, D.J. (2010) Proceedings of the National Academy of Sciences of the US.107(11):5196-201.

TRPV1: Contribution to Retinal Ganglion Cell Apoptosis and Increased Intracellular Ca2+ with Exposure to Hydrostatic Pressure
Sappington, R.M., Sidorova, T., Long, D.J. & Calkins, D.J. (2009)
Investigative Ophthalmology & Visual Science, 50:717-28.

Progressive ganglion cell degeneration precedes neuronal loss in a mouse model of glaucoma
Buckingham, B.P., Inman, D.M., Lambert, W., Oglesby, E., Calkins, D.J., Steele, M.R., Vetter, M.L., Marsh-Armstrong, N. & Horner, P.J. (2008)
Journal of Neuroscience, 28:2735-2744.

Contribution of TRPV1 to microglia-derived IL-6 and NFkappaB translocation with elevated hydrostatic pressure
Sappington, R.M. & Calkins, D.J. (2008)
Investigative Ophthalmology & Visual Science, 49:3004-17.

Manganese-enhanced MRI of the DBA/2J mouse model of hereditary glaucoma
Calkins, D.J., Horner, P.J., Roberts, R., Gradianu, M. & Berkowitz, B.A. (2008) Investigative Ophthalmology & Visual Science, 49:5083-5088.

Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T cell-derived Fas-ligand
Wax, M.B., Tezel, G., Yang, J., Peng, G., Patil, R.V., Agarwal, N., Sappington, R.M. & Calkins, D.J. (2008)
Journal of Neuroscience, 28:12085-12096.

A neurological perspective of glaucoma.
Calkins, D.J. (2008)
Glaucoma Today, September/October, pp. 18-20.

Retinal ganglion cells downregulate gene expression and lose their axons within the optic nerve head in a mouse glaucoma model
Soto, I., Oglesby, E., Buckingham, B.P., Son, J.L., Roberson, E.D., Steele, M.R., Inman, D.M., Vetter, M.L., Horner, P.J.& Marsh-Armstrong, N. (2008)
Journal of Neuroscience, 28:548-61.

Reduced retina microglial activation and improved optic nerve integrity with minocycline treatment in the DBA/2J mouse model of glaucoma
Bosco A., Inman, D.M., Steele, M.R., Wu, G., Soto, I., Marsh-Armstrong, N., Hubbard, W.C., Calkins, D.J., Horner, P.J.& Vetter, M.L. (2008)
Investigative Ophthalmology & Visual Science, 49:1437-46.

Quantitative Correlation of Optic Nerve Pathology with Ocular Pressure and Corneal Thickness in the DBA/2 Mouse Model of Glaucoma
Inman DM., Sappington, RM., Horner, PJ. & Calkins, DJ., (2006)
Investigative Ophthalmology & Visual Science, 47:986-996.

Pressure-Induced Regulation of IL-6 in Retinal Glial Cells: Involvement of the Ubiquitin/Proteasome Pathway and NF_B Sappington, RM. & Calkins, DJ. (2006)
Investigative Ophthalmology & Visual Science, 47:3860-3869.

Interleukin-6 Protects Retinal Ganglion Cells from Pressure-Induced Death
Sappington, RM., Chan M. & Calkins, DJ. (2006)
Investigative Ophthalmology & Visual Science, 47:2932-2942.

Microarray Analysis of Retinal Gene Expression in the DBA/2J Model of Glaucoma
Steele, MR., Inman DM., Calkins, D.J., Horner, P.J. & Vetter, M.L. (2006)
Investigative Ophthalmology & Visual Science, 47:977-985.

Abstracts

Marsh-Armstrong, N., Soto, I., Oglesby, E., Davis, C.-HO., Mules, EH., Valiente-Soriano, F., Vidal-Sanz, M., Buchman, V., Watkins, PA., Nguyen, JV., (2010) Gamma-Synuclein Aggregation and Activation of Optic Nerve Head Astrocytes (Investigative Ophthalmology & Visual Science, 51: ARVO E-Abstract 2100).

Breen, KT., Bosco, A., Fu, CT., Sretavan, DW, Vetter, ML (2010) Retinal Microglia Activate in a Mouse Model of Acute Ocular Hypertension (Investigative Ophthalmology & Visual Science, 51: ARVO E-Abstract 2097).

Inman, DM., Knox, JM., Morrison, RS., Horner, PJ. (2010) DBA/2J Mitochondria Morphology and Distribution Varies With Age and Increasing IOP (Investigative Ophthalmology & Visual Science, 51: ARVO E-Abstract 2140).

MacNamee, SE., Crish, SD., Juliao, SF., Lambert, WS., Calkins DJ. (2010) BDNF and TrkB Expression in the Retina of the DBA/2J Mouse Model of Glaucoma (Investigative Ophthalmology & Visual Science, 51: ARVO E-Abstract 2123).

Ho, KW., Juliao, SF., Zhao, B., Sappington, RM., Calkins DJ. (2010) Expression of the TRPV Family in the DBA/2J Mouse Model of Glaucoma (Investigative Ophthalmology & Visual Science, 51: ARVO E-Abstract 2125).

Zhao, B., Crish, SD., Calkins DJ. (2010) Dendritic Morphology Changes Prior to Uptake and Transport Dysfunction in Retinal Ganglion Cells of the DBA/2J Mouse Model of Glaucoma (Investigative Ophthalmology & Visual Science, 51: ARVO E-Abstract 2141).

Crish, SD., MacNamee, SE., Calkins DJ. (2010) Target Response to Axonal Transport Loss in Glaucoma (Investigative Ophthalmology & Visual Science, 51: ARVO E-Abstract 2142).

Dapper, JD., Crish, SD., Calkins DJ. (2010) Gene Expression Changes in Response to Age in the Superior Colliculus of the DBA/2J Mouse (Investigative Ophthalmology & Visual Science, 51: ARVO E-Abstract 2154).

Shih, GC., Sternberg, MG., Crish, SD., Harth, EM., Calkins DJ. (2010) Nanoparticle Drug Delivery to Retinal Ganglion Cells in Glaucoma (Investigative Ophthalmology & Visual Science, 51: ARVO E-Abstract 3167).

Sidorova, TN., Sappington, RM., Crish, SD., Lambert, WS., Calkins DJ. (2010) Cell Specific Localization of BDNF mRNA in the Mouse Visual Pathway Using Fluorescent in situ Hybridization (Investigative Ophthalmology & Visual Science, 51: ARVO E-Abstract 3173).

Lupien, C., Calkins DJ., Horner PJ. (2010) Decreasing Gliosis by Inhibition of the Stat3 Pathway in a Microbead Mouse Model of Glaucoma (Investigative Ophthalmology & Visual Science, 51: ARVO E-Abstract 3192).

Son, JL., Soto, I., Oglesby, E., Pease, ME., Quigley, HA., Marsh-Armstrong, N. (2009) Monitoring Glaucoma Progression in the Translimbal Trabecular Laser Photocoagulation Rat Model Using Molecular Markers (Investigative Ophthalmology & Visual Science, 50: ARVO E-Abstract 2764).

Bosco, A., Steele, MR., Luo, L., Ambati, BK., Vetter, ML. (2009) Characterization of GFP-expressing Microglia in DBA/2J-Cx3cr1 +/GFP Retina (Investigative Ophthalmology & Visual Science, 50: ARVO E-Abstract 2771).

Bosco, A., Steele, MR., Inman DM., Horner, PJ., Vetter, ML. (2009) Potential Role of Retinal Microglia in RGC Synapse Removal in DBA/2J Mice (Investigative Ophthalmology & Visual Science, 50: ARVO E-Abstract 2770).

Calkins DJ., Inman, P., Horner PJ., Crish, S. (2009) Progression of Deficits in Anterograde Active Axonal Transport in the Retina of the DBA/2J Mouse Model of Glaucoma (Investigative Ophthalmology & Visual Science, 50: ARVO E-Abstract 4317).

MacNamee, SE., Petty, B., Crish, SD., Calkins DJ.. (2009) Neurochemistry of RGC Axonal Dystrophies in the DBA/2J Mouse Model of Glaucoma (Investigative Ophthalmology & Visual Science, 50: ARVO E-Abstract 2767).

Inman, DM., Baltan, S., Calkins DJ., Horner PJ. (2009) High IOP Decreases Compound Action Potential Amplitude and Leads to Preferential Loss of Physiologically Identified Small Caliber Axons in DBA/2 Optic Nerve (Investigative Ophthalmology & Visual Science, 50: ARVO E-Abstract 2769).

Crish SD., Raymond, ID., Brecha, NC., Calkins DJ. (2009) Structural Persistence of the Retinal Ganglion Cell Projection in the DBA/2J Mouse Model of Pigmentary Glaucoma (Investigative Ophthalmology & Visual Science, 50: ARVO E-Abstract 2777).

Lupien, D., Inman, DM., Calkins DJ., Horner PJ. (2009) Tempering Gliosis by Inhibition of the NFkB Pathway in an Acute Model of Glaucoma (Investigative Ophthalmology & Visual Science, 50: ARVO E-Abstract 2781).

Armstrong, BK., Sappington-Calkins, RM., Calkins DJ., Russ, PK., Chang, MS. (2009) Antibodies Specific to the Extracellular Domain of Bves Lowers IOP (Investigative Ophthalmology & Visual Science, 50: ARVO E-Abstract 4057).

Calkins DJ, Roberts R, M. Gradianu, Berkowitz BA. (2008) Manganese-Enhanced MRI studies of intraretinal ionic activity in the DBA/2J mouse model of glaucoma (Investigative Ophthalmology & Visual Science, 49: ARVO E-Abstract 2878).

Wu G, Horner PJ, Calkins DJ. (2008) Age-dependent changes in morphologically identified glial cell populations in the optic nerve of the DBA/2J mouse model of pigmentary glaucoma (Investigative Ophthalmology & Visual Science, 49: ARVO E-Abstract 3693).

Crish SD, Balaram P, Inman DM, Horner PJ, Calkins DJ. (2008) Early transport deficits and distal axonopathy in the DBA/2J mouse model of pigmentary glaucoma (Investigative Ophthalmology & Visual Science, 49: ARVO E-Abstract 3664).

Balaram P, Crish SD, Calkins DJ. (2008) Upregulation of brain derived neurotrophic factor is related to transport loss in the superior colliculus of the DBA/2J mouse (Investigative Ophthalmology & Visual Science, 49: ARVO E-Abstract 4061).

Sappington RM, Sidorova TN, Calkins DJ. (2008) Trpv1 contributes to pressure-induced death and disruption of axonal transport in RGCs (Investigative Ophthalmology & Visual Science, 49: ARVO E-Abstract 5481).

Bosco A, Steele MR, Vetter ML. (2008) Microglia Cell Activation and Clustering Herald the Onset of Glaucoma in DBA/2J Retina. (Investigative Ophthalmology & Visual Science, 49: ARVO E-Abstract 5492).

Lambert W, Knox J, Steele MR, Bosco A, Wu G, Inman DM, Vetter ML, Calkins DJ, Horner PJ. (2008) Dietary Lipoic Acid Attenuates Oxidative Stress and Retinal Ganglion Cell Loss in the DBA/2J Mouse Model of Glaucoma (Investigative Ophthalmology & Visual Science, 49: ARVO E-Abstract 5498).

Inman DM, Horner PJ. (2008) Neurotrophin Receptor Expression in Retinal and Optic Nerve Microglia Changes With Glaucoma and Age in the DBA/2J Mouse Model (Investigative Ophthalmology & Visual Science, 49: ARVO E-Abstract 3703).

Lupien C, Inman DM, Horner PJ. (2008) Regulation of Gliosis in the DBA/2J Mouse Model of Glaucoma by NF-kB and STAT3 Pathways (Investigative Ophthalmology & Visual Science, 49: ARVO E-Abstract 5489).

Marsh-Armstrong N, Cox E, Soto I. (2008) Gamma synuclein changes cellular distribution in glaucomatous DBA/2J mice (Investigative Ophthalmology & Visual Science, 49: ARVO E-Abstract 5490).

Soto,I., Son,J., Marsh-Armstrong, N (2008) Proliferation and Oligodendrocyte Turnover in Optic Nerves of Glaucomatous DBA/2J Mice. (Investigative Ophthalmology & Visual Science, 49: ARVO E-Abstract 3687).

Soto, Son, Lopez-Roca, Oglesby & Marsh-Armstrong. Glial changes in the optic nerve correlate with axonal degeneration in a mouse glaucoma model. Molecular and Cellular Mechanisms of Axonal Degeneration Workshop. October 2008 Woods Hole, MA.

Bosco A, Steele MR, Vetter ML. Pathogenic Role Of Microglia In Early Stages Of Glaucoma. 2008 Cold Spring Harbor Laboratory Meeting on Glia in Health & Disease.

Gradianu, MD., Roberts, R., Inman, D., Horner, PJ., Calkins, DJ., Berkowitz, BA. (2007) Manganese-Enhanced MRI Studies of the DBA/2J Mouse Model of Glaucoma (Investigative Ophthalmology & Visual Science, 49: ARVO E-Abstract 1974).

Sappington, RM., Calkins, DJ.(2007) Shrinkage and Loss of RGC Axons in a New Latex Bead Rat Model of High-Pressure Glaucoma (Investigative Ophthalmology & Visual Science, 48: ARVO E-Abstract 2878).

Crish, SD., Sappington, RM., Calkins, DJ.(2007) Axon Degeneration and Loss of Transport in a New Latex Bead Model of High-Pressure Glaucoma (Investigative Ophthalmology & Visual Science, 48: ARVO E-Abstract 4352).

Long, DJ., Sappington, RM., Calkins, DJ.(2007) Pressure-induced Retraction of RGC Axons in an ex vivo Preparation of Rat Retina (Investigative Ophthalmology & Visual Science, 48: ARVO E-Abstract 4356).

Sappington, RM., Calkins, DJ.(2007) Elevated Pressure Induces TRPV1-Mediated Ca2+-Dependent Apoptosis of Retinal Ganglion Cells (Investigative Ophthalmology & Visual Science, 48: ARVO E-Abstract 4357).

Koh, JY., Sappington, RM., Calkins, DJ.(2007) Effects of TRPV1 Overexpression and Silencing on Retinal Ganglion Cell Survival in vitro (Investigative Ophthalmology & Visual Science, 48: ARVO E-Abstract 4358).

Joos, KM., Jones, A., Li, C., Calkins, DJ.(2007) Effect of Intermittent IOP Elevation Over 12 Weeks in the Rat Retinal Neurochemical Signature (Investigative Ophthalmology & Visual Science, 48: ARVO E-Abstract 3280).

Armstrong, BK., Sappington, RM., Sidorova, T.,Calkins, DJ.(2007) Activation of Glial Cells in a Latex Bead Rat Model of High Pressure Glaucoma (Investigative Ophthalmology & Visual Science, 48: ARVO E-Abstract 3282).

Inman, D., Bosco, A., Steele, MR., Wu, G., Calkins, DJ., Horner, PJ., Vetter, ML.(2007) Chronic Minocycline Treatment Decreases Microglial Activation and Improves Retrograde Axonal Transport in Retinal Ganglion Cells in DBA/2J Retina (Investigative Ophthalmology & Visual Science, 48: ARVO E-Abstract 3291).

Wu, G., Horner, PJ., Calkins, DJ..(2007) Morphometric Comparison of Age- and IOP-Dependent Changes in the Proximal and Distal Optic Nerve of the DBA/2J Mouse (Investigative Ophthalmology & Visual Science, 48: ARVO E-Abstract 3664).

Balaram, P., Calkins, DJ.(2007) Concentration-Dependent Protection of Retinal Ganglion Cells From Pressure-Induced Apoptosis by Pre-Treatment With a Flavonol Flavonoid (Investigative Ophthalmology & Visual Science, 48: ARVO E-Abstract 4944).

Marsh-Armstrong, N., Oglesby, E., Buckingham, B., Horner, PJ., Soto, I. (2007) Molecular Changes in DBA/2J Retinal Ganglion Cells Coinciding With Axonal Transport Dysfunction (Investigative Ophthalmology & Visual Science, 48: ARVO E-Abstract 5553).

Lupien, C., Horner, PJ.(2007) Stat3 Pathway in Glaucoma. A Study of the DBA/2J Mouse Model (Investigative Ophthalmology & Visual Science, 48: ARVO E-Abstract 5902).

Calkins, DJ., Koh, JY., Sappington, RM. (2006) TRPV1 Channels Modulate Pressure-Induced Death of Retinal Ganglion Cells (Investigative Ophthalmology & Visual Science, 47: ARVO E-Abstract 1557).

Armstrong, BK., Kehler, LA., Sappington, RM., Calkins, DJ.(2006) Müller Cell Activation Correlates with Photoreceptor Loss in DBA/2 Mice (Investigative Ophthalmology & Visual Science, 47: ARVO E-Abstract 1562).

Wax, MB., Tezel, G., Yang, J., Patil, R., Sappington, RM., Calkins, DJ.(2006) Induced Autoimmunity to Heat Shock Proteins Elicits Glaucomatous Loss of Retinal Ganglion Cells via a FAS/FAS-Ligand Pathway (Investigative Ophthalmology & Visual Science, 47: ARVO E-Abstract 1828).

Wu, G., Inman, D., Horner, PJ., Calkins, DJ. (2006) Selective Loss of Large-Caliber Axons in the Optic Nerve of the DBA/2J Mouse With Modest Increases in Intraocular Pressure (Investigative Ophthalmology & Visual Science, 47: ARVO E-Abstract 1829).

Koh, JY., Kammer, JA., Carlson, G., Wu, G., Calkins, DJ. (2006) Expression and Localization of FasL and CD95 in the DBA/2 Retina (Investigative Ophthalmology & Visual Science, 47: ARVO E-Abstract 5545).

Buckingham, BP., Inman, D., Calkins, DJ., Horner, PJ. (2006) Retrograde Transport is Significantly Reduced Prior to RGC Death in the DBA Mouse Model of Glaucoma (Investigative Ophthalmology & Visual Science, 47: ARVO E-Abstract 1237).

Sappington, RM., Calkins, DJ. (2006) TRPV1 Modulates Pressure-Induced Interleukin-6 Release by Retinal Microglia (Investigative Ophthalmology & Visual Science, 47: ARVO E-Abstract 1266).

Carlson, BJ., Sappington, RM., Calkins, DJ.(2006) Metabotropic Glutamate Receptor 1 : Implications for Vascular Permeability in the DBA/2 Mouse Model of Glaucoma (Investigative Ophthalmology & Visual Science, 47: ARVO E-Abstract 1272).

Inman, DM., Horner, PJ. (2006) Potential Impact of Glial Hypertrophy and Proteoglycan Changes on Retinal Ganglion Cell Function in the DBA/2 Mouse Model of Glaucoma (Investigative Ophthalmology & Visual Science, 47: ARVO E-Abstract 1576).

Lambert, WS., Inman, DM., Horner, PJ. (2006) Ceruloplasmin Expression in the DBA/2 Mouse Model of Glaucoma (Investigative Ophthalmology & Visual Science, 47: ARVO E-Abstract 1241).

Calkins, DJ., Sappington, RM. (2005) Pressure-Induced Production of Inflammatory Cytokines and Activation of NF B Is Modulated by Calcium Channels in Retinal Glia (Investigative Ophthalmology & Visual Science, 46: ARVO E-Abstract 3579).

Inman, DM., Buckingham, BP., Sappington, RM., Calkins, DJ., Horner, PJ.(2005) Retinal Vessel Volume and Pericyte Number Decrease Over Time in the DBA/2 Mouse Model of Glaucoma (Investigative Ophthalmology & Visual Science, 46: ARVO E-Abstract 1320).

Steele, M., Inman, DM., Sappington, RM., Golestaneh, N., Marsh-Armstrong, N., Calkins, DJ., Horner, PJ., Vetter, ML. (2005) Whole Retinal Microarray Analysis of DBA/2J Mice: A Model for Glaucoma (Investigative Ophthalmology & Visual Science, 46: ARVO E-Abstract 48).

Buckingham, BP., Inman, D., Horner, PJ. (2005) RGC Cell Death or Axon Transport Defect in a Mouse Model of Glaucoma (Investigative Ophthalmology & Visual Science, 46: ARVO E-Abstract 3803).

Marsh-Armstrong, N., Hwang, H.-W., Steele, M., Callahan, E., Vetter, ML. (2005) Early Retina Progenitor Specific Expression of Frizzled-5 BAC and Enhancer (Investigative Ophthalmology & Visual Science, 46: ARVO E-Abstract 3240).

Last reviewed on March 18, 2013

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