print this page | email this page
Catalyst For a Cure Publications and Abstracts (2008)
In 2008, the Catalyst for a Cure research scientists achieved peer acknowledgement in key science publications.
Papers and manuscripts:
Buckingham, B.P., Inman, D.M., Lambert, W., Oglesby, E., Calkins, D.J., Steele, M.R., Vetter, M.L., Marsh-Armstrong, N. & Horner, P.J. (2008) Progressive ganglion cell degeneration precedes neuronal loss in a mouse model of glaucoma (J. Neurosci., 28, 2735-2744).
Sappington, R.M. & Calkins, D.J. (2008) Pressure-induced translocation of NFkB and IL- 6 release in retinal microglia involves Ca2+ and TRPV1 (Inv. Ophthal. Vis. Sci., 49, 3004- 3017).
Calkins, D.J., Horner, P.J., Roberts, R., Gradianu, M. & Berkowitz, B.A. (2008) Manganese-enhanced MRI of the DBA/2J mouse model of hereditary glaucoma (Inv. Ophthal. Vis. Sci., 49, 5083-5088.).
Wax, M.B., Tezel, G., Yang, J., Peng, G., Patil, R.V., Agarwal, N., Sappington, R.M., Calkins, D.J. (2008) Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T cell-derived Fas-ligand (J. Neurosci., 28, 12085-12096).
Calkins, D.J. (2008) A neurological perspective of glaucoma. (Glaucoma Today, September/October, pp. 18-20).
Sappington, R.M., Sidorova, T., Long, D.J. & Calkins, D.J. (2009) The role of TRPV1 in retinal ganglion cell apoptosis and increased intracellular Ca2+ with exposure to hydrostatic pressure (in press, Inv. Ophthal. Vis. Sci).
Soto, I., Oglesby, E., Buckingham, B.P., Son, J.L., Roberson, E.D., Steele, M.R., Inman, D.M., Vetter, M.L., Horner, P.J., Marsh-Armstrong, N. (2008) Retinal ganglion cells downregulate gene expression and lose their axons within the optic nerve head in a mouse glaucoma model. J. Neurosci., 28:548-61.
Bosco A., Inman, D.M., Steele, M.R., Wu, G., Soto, I., Marsh-Armstrong, N., Hubbard, W.C., Calkins, D.J., Horner, P.J., Vetter, M.L. (2008) Reduced retina microglial activation and improved optic nerve integrity with minocycline treatment in the DBA/2J mouse model of glaucoma. Invest Ophthalmol Vis Sci. 49:1437-46.
Abstracts:
Calkins DJ, Roberts R, M. Gradianu, Berkowitz BA. Manganese-Enhanced MRI studies of intraretinal ionic activity in the DBA/2J mouse model of glaucoma. Invest. Ophthalmol. Vis. Sci. 2008; ARVO E-Abstract 2878. 11
Wu G, Horner PJ, Calkins DJ. Age-dependent changes in morphologically identified glial cell populations in the optic nerve of the DBA/2J mouse model of pigmentary glaucoma. Invest. Ophthalmol. Vis. Sci. 2008; ARVO E-Abstract 3693.
Crish SD, Balaram P, Inman DM, Horner PJ, Calkins DJ. Early transport deficits and distal axonopathy in the DBA/2J mouse model of pigmentary glaucoma. Invest. Ophthalmol. Vis. Sci. 2008; ARVO E-Abstract 3664.
Balaram P, Crish SD, Calkins DJ. Upregulation of brain derived neurotrophic factor is related to transport loss in the superior colliculus of the DBA/2J mouse. Invest. Ophthalmol. Vis. Sci. 2008; ARVO E-Abstract 4061.
Sappington RM, Sidorova TN, Calkins DJ. Trpv1 contributes to pressure-induced death and disruption of axonal transport in RGCs. Invest. Ophthalmol. Vis. Sci. 2008; ARVO EAbstract 5481.
Bosco A, Steele MR, Vetter ML. Microglia Cell Activation and Clustering Herald the Onset of Glaucoma in DBA/2J Retina. Invest. Ophthalmol. Vis. Sci. 2008; ARVO EAbstract 5492.
Lambert W, Knox J, Steele MR, Bosco A, Wu G, Inman DM, Vetter ML, Calkins DJ, Horner PJ. Dietary Lipoic Acid Attenuates Oxidative Stress and Retinal Ganglion Cell Loss in the DBA/2J Mouse Model of Glaucoma. Invest. Ophthalmol. Vis. Sci. 2008; ARVO E-Abstract 5498.
Inman DM, Horner PJ. Neurotrophin Receptor Expression in Retinal and Optic Nerve Microglia Changes With Glaucoma and Age in the DBA/2J Mouse Model. Invest. Ophthalmol. Vis. Sci. 2008; ARVO E-Abstract 3703.
Lupien C, Inman DM, Horner PJ. Regulation of Gliosis in the DBA/2J Mouse Model of Glaucoma by NF-kB and STAT3 Pathways. Invest. Ophthalmol. Vis. Sci. 2008; ARVO EAbstract 5489.
Marsh-Armstrong N, Cox E, Soto I. Gamma synuclein changes cellular distribution in glaucomatous DBA/2J mice. Invest. Ophthalmol. Vis. Sci. 2008; ARVO E-Abstract 5490.
I. Soto, J. Son, N. Marsh-Armstrong. Proliferation and Oligodendrocyte Turnover in Optic Nerves of Glaucomatous DBA/2J Mice. Invest. Ophthalmol. Vis. Sci. 2008; ARVO EAbstract 3687.
Soto, Son, Lopez-Roca, Oglesby & Marsh-Armstrong. Glial changes in the optic nerve correlate with axonal degeneration in a mouse glaucoma model. Molecular and Cellular Mechanisms of Axonal Degeneration Workshop. October 2008 Woods Hole, MA.
Bosco A, Steele MR, Vetter ML. Pathogenic Role Of Microglia In Early Stages Of Glaucoma. 2008 Cold Spring Harbor Laboratory Meeting on Glia in Health & Disease.